[5] In 2000, Khalifé moved to New York City to study piano with Hungarian pianist Gyorgy Sandor at the Juilliard School of Music.

4 and Ravel's piano concerto in G.[5] Khalifé has performed in the Middle East and the United States as a solo artist as well as with clarinetist Kinan Azmeh, often playing classical works as well as improvised compositions.

[8] In 2006, Khalifé performed at the University of Michigan's Hill Auditorium as part of the Arab World Music Summit.

[2] In 2013, Khalifé performed original music inspired by the Arab Spring called Requiem for Beirut at the Qatar Philharmonic Orchestra and the MDR Leipzig Radio Choir.

[4][11][12] In May 2017, he performed his work, Voyage with Marcel Khalifé at the Philharmonie de Paris with his father and at the Orchestre national d'Île-de-France, conducted by Julien Leroy.

[16] Aufgang then became a three person project with Khalifé, Francesco Tristano, and Aymeric Westrich, with a record deal with the French label InFiné.

[21] In 2016, the group released a collaborative record called Andalusia of Love, a mixture of traditional music inspired by the Palestinian writer Mahmoud Darwish and improvised compositions from Rami and Bachar.

[24] Khalifé lives in Paris with his wife, ABC Broadcast Journalist Mariam Saab[25] and their two children.