The station is also on a section shared with the Be'er Sheva–Tel Aviv line, which branches out in a southerly direction about 3 km east of Ramla.

[2] During the unrest of the 1947–1948 Civil War in Mandatory Palestine the original station building was bombed by the Irgun on 27 May 1947.

As part of the double-tracking and upgrading project of the Lod–Beersheba main line, the size of the station was doubled in 2012.

When suburban service to the Rehovot railway station, on the Lod–Ashkelon line commenced in 1990, a halt named Ramla West constructed on the line just south of the then-level crossing (now grade separation) with Road 44.

There is hourly train service in each direction to and from Tel Aviv and Beit Shemesh, and a half-hourly train service in each direction to Nahariya via Tel Aviv and Haifa and Beersheba via Kiryat Gat.