Mănescu also has an MA in "International Relations and European Integration" from the National School of Administration and Political Science of Bucharest (2006).

[citation needed] From 2002 until 2005 she was part of the Executive Committee of District 6 of the NLP and then, for two years (2002–2004), she has worked as a Parliamentary Expert in the Romanian Parliament, serving as adviser to the vice-president of the Commission of Defense, Internal Affairs and National Security in the Chamber of Deputies.

She then became increasingly involved in projects that aim to support young people, which lead to her becoming a vice-president of the National Authority for Youth, with the rank of Under Secretary of State (2005–2007).

She has been a lecturer for several conferences: "Conflict management - training young people", "Regional Development Partnership", "Globalization, 90 years of Romanian Diplomacy" (2003) and coordinator of the project "Human Rights and International Law", Strasbourg, France (2003)[citation needed] She is a Member of the European Parliament (2007–present).

[6] Mănescu aims to promote the real priorities of Romania in the European Parliament, through a constant "lobbying" activity set to protect the rights of Romanian citizens and their interests.

[citation needed] As a coordinator of programmes in the field of youth, Mănescu has contributed to the organisation of a number of events, among which: During her legislative terms as an MEP, Manescu has defended the Azerbaijani regime against the criticism of the European Parliament.

In 2015, following the adoption of a resolution criticizing the crack-down on the human rights and oppression of the freedom of expression in the country by the European Parliament,[8] Mănescu made a statement supporting Azerbaijan.

According to the report with a title “European Values Bought and Sold, An exploration into Azerbaijan’s sophisticated system of projecting its international influence, buying Western politicians and capturing intergovernmental organisations”,[10] in 2016 Mănescu joined the European People's Party delegation for an observation mission of the controversial constitutional referendum in Azerbaijan.