He is serving as Federal Minister for Industries and Production and National Food Security and Research since March 2024.
[2][5] A leader of the Pakistan Muslim League (N), Hussain briefly held the cabinet portfolio of Minister for Defence Production during the Gillani ministry in 2008.
[13] He had ceased to hold ministerial office in July 2017 when the federal cabinet was disbanded following the disqualification of Prime Minister Nawaz Sharif after Panama Papers case decision.
[18][19] On 3 May 2018, in a cabinet reshuffle, he ceased to hold the office as Federal Minister for Defence Production after Usman Ibrahim succeeded him.
[20] Upon the dissolution of the National Assembly on the expiration of its term on 31 May 2018, Hussain ceased to hold the office as Federal Minister for Science and Technology.
[21] He was re-elected to the National Assembly as a candidate of PML-N from Constituency NA-120 (Sheikhupura-II) in 2018 Pakistani general election.