[3] It is named for Horace Randal, a Confederate brigadier general killed at the Battle of Jenkins Ferry.

At one time, the large JA Ranch, founded by Charles Goodnight and John George Adair, which reached into six counties, held acreage in Randall County.

As of the census[10] of 2000, 104,312 people, 41,240 households, and 28,785 families resided in the county.

The racial makeup of the county was 90.44% White, 1.50% Black or African American, 0.65% Native American, 1.03% Asian, 0.03% Pacific Islander, 4.71% from other races, and 1.64% from two or more races.

The Republican candidate has carried the county in every presidential election since 1952, usually by overwhelming margins.

School districts include:[15] All of the county is in the service area of Amarillo College.