Bang!, Mighty Med, Childrens Hospital, Law & Order, Becker, Providence, The Oblongs (as conjoined twin brothers Biff and Chip Oblong), Entourage, Grey's Anatomy (as conjoined twin brothers Peter and Jake Weitzman), Curb Your Enthusiasm (Jason only), and It's Always Sunny in Philadelphia (as dance marathon DJs on the episode "The Gang Dances Their Asses Off").

They were featured in the Troma production Citizen Toxie: The Toxic Avenger IV as Jason Gonzalez and Randy Diaz, a pair of Tromaville news anchormen.

In August 2010, they made a cameo appearance in the web comedy The Legend of Neil in season 3 episode 3, depicting two football-loving "Armos" statues.

The brothers uniquely framed their special as if it were an NFL playoff game with Rich Eisen leading a roundtable discussion of the brothers' comedy on an NFL Network set, along with future Hall of Fame defensive lineman Dwight Freeney, NY Giants defensive back Terrell Thomas, and actor and former Georgia Bulldog football player Omar Dorsey.

In addition, the ubiquitous sideline reporter Bonnie Bernstein makes a cameo, interviewing the brothers pre- and post-show.

Jason is married to Jessica Zucker, a fertility therapist who created her own line of critically acclaimed pregnancy loss cards.

The brothers co-wrote with Nick Kroll the web series Layers, directed by Michael Blieden, on which they played twin publicists Larry and Terry Bridge.

In 2010, the online network Crackle released Held Up, an original series written by the brothers and starring Kaitlin Olson of It's Always Sunny in Philadelphia.

A "by the numbers" series, it featured interesting statistics about the U.S., mixed with experiments, stunts, and the Sklars' unique brand of humor.

From August 2010 to 2017[5] the Sklar Brothers hosted a popular weekly podcast called Sklarbro Country on the Earwolf network.

They described the podcast as the intersection of sports, comedy, and indie rock, and the show had guests ranging from Jon Hamm to Terrell Owens to Diablo Cody.

Memorable episodes featured Richard Simmons, Patton Oswalt, the end of the year Character Specials, Hamm, Rich Eisen, and Adam Carolla.

Described as a shorter midweek snack of an episode, the show is co-hosted by up and coming character comedic actor Dan Van Kirk.

Randy has described the show this way: "If a 30-person brawl breaks out at a Chuck E. Cheese in Tampa, FL at a 5-year-old's birthday party and the fight spills over into a Burlington Coat Factory parking lot, ending in someone defecating in an ex-boyfriend's hatchback… we'll be there to make fun of it."

The Sklar brothers made two cameo appearances on AMC's Better Call Saul as the owners of a music shop who are purchasing television commercials from the suspended lawyer Jimmy McGill.

[8] The Sklar Brothers later auditioned in season sixteen of America's Got Talent where their comedy act enabled them to advance to the next round.