She shared screen space with prominent actors including M. G. Ramachandran, Sivaji Ganesan, Rajinikanth, Kamal Haasan, Vijay, Ajith Kumar and Vishal during her illustrious career.
[9] She appeared in song sequence "Yaaro Yaarodi Unnoda Purushan" in Alai Payuthey (2000) starring opposite Shalini Ajith.
Her most notable iconic memorable comedy performance came in Kee Mu (2008) where she collaborated with Vadivelu in a scene involving a stray dog where she says, "porathu than pora appdiye antha naaya shunnu sollitu poppa", "karuppa irukkuravana kadikkathunu ninaichi sonnen".
During the latter part of her life, she sold handkerchiefs and handicrafts to people at Marina Beach in Chennai for her livelihood as she struggled to cope with the economic situation owing to a lack of film opportunities.
However, Rangammal herself claimed that she got inspiration from her idol MGR to work hard in order to earn money and refuted rumors about her being left out by people around her, which propelled her to sell handkerchiefs at the beach.