In 2013, Dwamena helped the RB Ghana U17 team to a silver medal performance, and was named the tournament's Best Player.

[2] Before returning to Ghana, Dwamena and his teammate, David Atanga, first travelled to Austria for a one-week trial with Red Bull Salzburg.

[5] In July 2014, Dwamena was promoted to FC Liefering, the Salzburg farm team playing in the Austrian Football First League.

[8][9] Dwamena enjoyed a successful half-season with Austria Lustenau, scoring 18 goals in 20 games, before his transfer to FC Zürich.

[citation needed] On 21 August 2017, Zürich agreed a fee with Premier League club Brighton & Hove Albion for the transfer of Dwamena.

[16] In October 2019, after new examinations were carried out on his heart condition, the doctors recommended his immediate withdrawal and retirement from football.

[23] Due to his heart condition and some worrying measurements, Vejle confirmed on 26 October 2020, that Dwamena could not play for a period.

[18][22] In October 2020, the ICD showed values which were considered too high, and his club at the time, Vejle Boldklub, withdrew him from team activities as a result.

[22] In October 2021, in Austrian Cup match during the first half of Blau-Weiss Linz's game against Hartberg, Dwamena collapsed on pitch, was shocked by the ICD and stabilized quickly.

[34] On 11 November 2023, Dwamena collapsed into sudden cardiac arrest on the field in the 23rd minute of the first half of the round 13 match between Egnatia and Partizani in the Kategoria Superiore, and died on the way to Kavajë Hospital, aged 28.