Their longest-running number-one, a cover of Marcus Hummon's "Bless the Broken Road", spent five weeks at number one on Hot Country Songs in 2005.

The band has also found commercial success with a cover of Tom Cochrane's "Life Is a Highway", which they recorded for the soundtrack of the Disney/Pixar animated film Cars (2006).

After he'd heard the demos, the band went into the Lyric Street offices the next day, sat down with acoustic guitars, and played a couple of songs.

The music video for "I Melt" garnered controversy for its scenes which featured partial nudity,[10] and was banned from the Great American Country network.

The song was released as a single under the title "Skin (Sarabeth)" and officially added to the album's track list, later peaking at #2 on the country charts.

In the summer of 2006, the group charted in the top 10 of the Hot 100 again with a cover of Tom Cochrane's "Life Is a Highway", which they recorded for the Disney/Pixar film Cars.

[12] The album's success led the band to take the spot of top-selling artist for all genres of music, which had not been accomplished in 15 years by a country group.

A year later in October 2009, they released a second edition of their greatest hits collection, this time with a second disc containing live performances of "Take Me There", "Summer Nights", "Me & My Gang", and "Winner at a Losing Game".

In April 2009, the band contributed re-recordings of their songs "Bless the Broken Road" and "Backwards" for the soundtrack of Hannah Montana: The Movie (2009), which they also appeared in.

On July 16, 2009, as part of the American Living Tour, Rascal Flatts made history as the first country music group to play Chicago's Wrigley Field.

[19][20] On November 19, Rascal Flatts released a DVD, All Access & Uncovered: The Making of Changed and Beyond, inviting the public into their inner circle.

[25] Rascal Flatts and Journey headlined the Super Bowl XLVII CMT Crossroads concert at the New Orleans Sugar Mill on February 2, 2013.

In June 2012, Rascal Flatts closed the CMT Music Awards by inviting Journey to perform their hit "Don't Stop Believin'" with them on stage.

In response to the controversy, Rascal Flatts communicated afterwards that LeVox had lost his voice and so they made a last-minute decision to lip-sync.

Rewind produced three more singles with "Payback", which peaked at 21, "Riot", which reached 20, and "I Like the Sound of That", which was released to country radio on September 14, 2015.

[42] On April 27, 2021, DeMarcus stated in an interview with Taste of Country that the pandemic may have altered the band's plans for a farewell tour, and that they may stay together and perform 10-15 concerts annually.

"[44] DeMarcus and Rooney appeared at the 2021 Academy of Country Music Honors show on August 25 to receive the Cliffie Stone Icon Award on behalf of the group, though LeVox was not present.

LeVox also revealed he had not spoken to Rooney since his DUI arrest on September 10 and that the group quietly disbanded after the cancellation of their farewell tour.

[45] In 2020, DeMarcus formed a new band called Generation Radio alongside ex-Chicago vocalist Jason Scheff, Journey drummer Deen Castronovo, Chris Rodriguez and former Rascal Flatts live instrumentalist Tom Yankton.

Their eponymous debut album, released on August 12, 2022, features a new rendition of Rascal Flatts' song "All Night to Get There", with DeMarcus on lead vocals.

[49] On January 20, 2025, Rascal Flatts performed together for the first time in nearly five years at the Commander in Chief Ball during the second inauguration of Donald Trump.

[50] On January 31, the group released a new single entitled "I Dare You" featuring the American pop rock band Jonas Brothers.

[52] Brian Mansfield of USA Today explained: "Rascal Flatts—with clean-cut looks, showy vocals and pop-influenced arrangements—quickly found fans, as well as detractors willing to lump them with the boy-band knockoffs."

'"[53] The band has cited Alabama, the Eagles,[54] Shenandoah, George Jones, Earl Thomas Conley, Keith Whitley, Stevie Wonder, Eric Clapton, Merle Haggard, Johnny Cash, Jeff Beck and Vince Gill as some of their most prominent musical influences.

DeMarcus said: "Some of my biggest commercial musical influences would be people like Merle Haggard, George Jones, of course, Johnny Cash.

[57] Rascal Flatts has helped support music education in disadvantaged U.S. public schools by filming a PSA with Little Kids Rock.

[59] Their chart-topping song, "My Wish" is also used on ESPN as the soundtrack for its series that follows the Make-a-Wish Foundation as they turn dreams into reality for children with life-threatening illnesses.

In September 2007, Weekly Reader Research conducted a poll of more than 2,000 children and Rascal Flatts ranked as the sixth-most-popular act among ages 10–12.

[69] On April 9, 2013, the group announced that they would co-headline a show with Journey on August 1 at Hersheypark Stadium with The Band Perry and Cassadee Pope as openers.

On the commentary they said what a great opportunity it was to work with such fine actors who are so good at what they do, LeVox stated, "It's one of my favorite shows and it was an honor to add a little piece of Rascal Flatts to the episode."