In the 2006–07 season, led by Head coach Mike Taylor and Assistant coach Rainer Bauer the team headed into their first season in the Basketball Bundesliga as the team with the smallest funds and the smallest arena in the league.

Still a club with one of the smallest funds in the league, the team experienced some major changes in the pre-season of their second year in the Bundesliga because starting point guard Austen Rowland and shooting guard Jonathan Levy left the team while starting small forward Emeka Erege received a serious injury during an exhibition game.

After a very good season in 2008–09, Ulm lost the league's best rebounder and most efficient player Jeff Gibbs to Eisbären Bremerhaven.

In the 2012–13 season Ulm entered a European competition for the first time, in the 2012–13 Eurocup, the team reached the quarterfinals.

Ulm reached the BBL semi-finals and lost in the German Cup Final, 67–85 against Alba Berlin, as well that season.

The club ended in the first place of the regular season with 30 wins and just 2 losses,[6] but could not achieve the title as it lost in the semi-finals of the playoffs by EWE Baskets Oldenburg.

[8] On 16 June 2023, Ulm won their first-ever national championship after winning the 2022–23 Basketball Bundesliga season.