M&T Bank bought the naming rights in 2003 and signed a 15-year, $75 million contract with the Ravens, which was brokered by Team Services, LLC.

Although there was some sentiment from Baltimore residents in having the Ravens stay there permanently, it was deemed too old to host an NFL team.

The plaza formerly featured large banners, each containing a picture of Unitas in his playing days, flanking the stadium entrance.

The bronze figure depicts Lewis in the final pose of his iconic "squirrel dance", which he performed before every Ravens home game upon coming on to the field.

In December 2015, the Ravens announced that in 2016 the team would go back to natural grass playing surface, which is currently Tifway 419 Bermudagrass.

Every Thanksgiving, Loyola Blakefield and Calvert Hall College also square off in what has now been called for many years as the Turkey Bowl, usually reaching up to 13,000 people in the audience.

On July 24, 2009, English Premier League club Chelsea won 2–1 against Italian Serie A team AC Milan in the first World Football Challenge at M&T Bank Stadium in front of a crowd of 71,203.

[19] On July 28, 2012 the stadium hosted a match between Premier League teams Liverpool and Tottenham Hotspur before 42,723 fans.

[20] The stadium was a venue for the 2013 CONCACAF Gold Cup, drawing a crowd of 70,450 to watch a quarter finals doubleheader between the United States v. El Salvador, and Honduras v. Costa Rica.

[21] The 2015 CONCACAF Gold Cup had two quarterfinals games at the stadium: United States v. Cuba and Haiti v. Jamaica, played in front of 37,994 spectators.

Popular music festival HFStival appeared at the stadium in 1999 & 2005, as Foo Fighters, Red Hot Chili Peppers, Silverchair, The Mighty Mighty Bosstones, The Offspring, Blink-182, Goo Goo Dolls, Billy Idol, and Coldplay have all played the concert.

[25] The stadium was supposed to be the location of the football game in the 2002 film The Sum of All Fears and included footage of the presidential motorcade going to the building.

[26] It was featured in "Stadium," a 2013 television public service announcement which was part of the "I Want To Be Recycled" advertising campaign for Keep America Beautiful and the Ad Council.

[27][28] On February 25, 2021, despite COVID-19 pandemic, M&T Bank Stadium became the third mass vaccination site in the state of Maryland, inoculating residents against COVID-19, according to the Johns Hopkins University (JHU).