He is best known for his role as Little Carmine Lupertazzi in The Sopranos, Detective Michael McGuire in The Practice (1998–2004), and Tony Giuliano in Night Court (1989–1991).

He is a graduate of Christ the King Regional High School in Middle Village, Queens, New York.

He also played the part of Tony Guiliano, Christine Sullivan's fiancé, husband, and then ex-husband in several episodes of the sitcom Night Court.

Other television credits include a 1989 episode of Empty Nest, where he played cardiologist Dr. Leonard, NCIS, Murder, She Wrote, L.A. Law, House M.D., NYPD Blue, Lois and Clark, Law & Order: SVU, The Nanny, CSI: NY, Criminal Minds, Bones, Weinerville (head writer, stage manager, and performed as the puppet chef Pops), In Plain Sight and Mad Men.

Abruzzo starred in the longest single shot movie in American film history,[2] Somebody Marry Me, written and directed by John Asher.