He went on to play a leading role in Tanika Gupta's The Empress for the Royal Shakespeare Company directed by Emma Rice.

[12][13][14][15] In 2014, he was announced as one of 18 BAFTA 'Breakthrough Brits' a celebration of Britain's stars of tomorrow alongside fellow actors Stacy Martin, Katie Leung and Callum Turner.

[16] In 2016, Panthaki was cast as DCI Rav Sangha in Hans Rosenfeldt's Nordic noir detective series Marcella.

[19] In 2020 Panthaki appeared in the Netflix Original series Away, alongside Hilary Swank, as Group Captain Ram Arya, second in command on a mission to Mars.

[20] In 2021 Panthaki was nominated for the BIFA for Best Supporting Actor at the British Independent Film Awards 2021 for his role as Freeman in Boiling Point alongside Stephen Graham.