He was born in New York City and was raised in Levittown, a neighborhood in Toa Baja, Puerto Rico, the son of Ramon Reyes and Carmen Leon.

Ray's first album with Menudo was 1983's A Todo Rock, where he sang lead vocals on "Si Tu No Estas", "Chicle De Amor", and "Zumbador".

In 1997 he came up with the idea of doing an ex Menudos' concert and reunited 6 of the golden era with former Menudo bandmates Miguel Cancel, Ricky Melendez, Charlie Massó and Johnny Lozada as well as Farrait for a single concert named El Reencuentro in the Roberto Clemente Coliseum (12,000 capacity) in San Juan.

[2][3] He produced their gold-certified live album El Reencuentro: 15 Años Después released by Fonovisa Records.

His younger brother Raul Reyes, who was his lifetime musical collaborator, also participated by recording backing vocals, helping the group in several TV Commercials, Menudo TV Specials and the record productions, A Todo Rock, Menudo Mania, Reaching Out, and Evolucion as well with Proyecto M & El Reencuentro productions.

Per the documentary 'Menendez + Menudo: Boys Betrayed,' prior to his death, Reyes was working to expose the years of child sexual abuse allegedly committed against dozens of young boys by Menudo founder Edgardo Diaz, which also allegedly involved RCA executive José Menendez, who, along with his wife, Kitty, was later slain by his sons Lyle and Erik after many years of alleged child sexual abuse committed against them.