van Barneveld is also a two-time UK Open champion, and a former winner of the Las Vegas Desert Classic, the Grand Slam and the Premier League.

[3][4] On 28 March 2019, following a 7–1 defeat to Michael van Gerwen in his final Premier League match, he announced his retirement with immediate effect,[5] but reversed his decision the following day.

He won his first major PDC title in June by beating Barrie Bates in the final of the UK Open at the Reebok Stadium, Bolton.

A month later, he continued his surge of major titles by beating Terry Jenkins 13 legs to 6 in the final of the 2007 Las Vegas Desert Classic.

[11] The feat earned Van Barneveld £20,000 – the bonus had not been won since Taylor's nine-darter at the UK Open against Jamie Harvey – as he became the first player to throw a perfect leg in the PDC World Championship.

Van Barneveld threw his fourth nine dart finish in the Blue Square UK Open West Midlands Regional on 29 March 2009 in the third round against Kirk Shepherd.

Van Barneveld was considering retiring from the sport, but he stated after his first-round win in the 2009 World Grand Prix over Alan Tabern that he was suffering from diabetes and his absence was in order to get fit and healthy and going to the gym.

Together they enjoyed comfortable victories over Austria and Northern Ireland to set up a semi-final clash with the Australian pair of Paul Nicholson and Simon Whitlock.

[19] Van Barneveld won the UK Open Qualifier 5 by beating Andy Smith 6–3 in the final, after earlier overcoming Simon Whitlock and Terry Jenkins.

[31] After all 33 ProTour events of 2012 had been played, Van Barneveld finished fourth on the Order of Merit to qualify for the Players Championship Finals where he lost 6–5 to Steve Beaton in the first round.

[32][33] Van Barneveld began the 2013 World Championship by throwing the sixth highest average in the history of the tournament in his first round 3–0 defeat of Michael Smith.

[38] In his third World Cup of Darts and first with Michael van Gerwen, the Dutch pair suffered a shock in the last 16 when they were beaten 5–3 by the Finnish duo of Jani Haavisto and Jarkko Komula.

[43] Van Barneveld defeated defending champion Robert Thornton in the last 16 of the 2013 UK Open and survived one match dart from Ronnie Baxter in the quarter-finals to win 10–9.

[46][47] Van Barneveld put his bad form behind him in October by securing his first ranking title of 2013 at the tenth Players Championship of the year with a 6–3 defeat of Peter Wright in the final.

[49] In the defence of his Grand Slam of Darts title he beat Ricky Evans and Tony O'Shea, but lost his final group game against Mervyn King to be knocked out of the competition on leg difference.

[51] He had a poor run of form in the UK Open Qualifiers to be placed 66th on the Order of Merit meaning he entered the tournament in the first-round stage.

[58] Early on in his second round match against Mervyn King at the World Grand Prix, Van Barneveld was visibly struggling with a back problem but battled to trail 2–1 in sets.

[59] At the next major event, the European Championship, Van Barneveld wore glasses during a match for the first time in his career and explained after his 6–4 first round win over Simon Whitlock that his diabetes can occasionally blur his vision.

[62] He lost to newcomer Keegan Brown 10–7 in the last 16 of the Grand Slam and was drawn to face Van Gerwen in the first round again this time at the Players Championship Finals where he was defeated 6–2.

[67] Van Barneveld looked to have got himself back into his semi-final meeting with Phil Taylor when he recovered from 2–0 down to draw level, but his lengthy previous matches seemed to take effect as he could not win another set to be defeated 6–2.

[68] At the Masters he knocked out newly crowned world champion Gary Anderson 11–6 in the semi-finals, but was beaten by a reversal of this scoreline against Michael van Gerwen in the final.

[69] He eliminated reigning champion Adrian Lewis 9–3 at the UK Open, but then lost a televised match against Peter Wright for the first time as he was comprehensively beaten 9–1.

[77] Van Barneveld beat Larry Butler to qualify from his group at the Grand Slam and then came past James Wade 10–7 and Mark Webster 16–12 to reach the semi-finals, where he lost 16–12 to Taylor.

In the final set he survived one match dart from Smith and Van Barneveld won four legs in a row to move into the semi-finals where he played Adrian Lewis.

[85] He did not drop a set in reaching the semi-finals of the World Grand Prix as he overcame Mervyn King, Lewis and Benito van de Pas, but was defeated 4–1 by Gary Anderson.

[86] At the Grand Slam, Van Barneveld averaged over 100 in each of his three group games to top the table and then saw off the BDO's number one Glen Durrant 10–7 to play Anderson in the quarter-finals.

[95] Partnering Van Gerwen at the 2018 PDC World Cup of Darts, the Dutch duo retained their title, beating the Scotland pair of Gary Anderson and Peter Wright.

Van Barneveld's run to the final included a 6–1 win against Darius Labanauskas in the last 16, a 6–2 triumph over Alan Soutar at the quarter-final stage and a 7–3 victory in the semi-finals against Ian White.

[109][110] At the 2024 World Championship, van Barneveld achieved wins over Radek Szagański and Jim Williams, before losing 4–1 to eventual runner-up Luke Littler in the fourth round.

In October 2009, during the World Grand Prix tournament in Ireland, Van Barneveld revealed that he had been diagnosed with type 2 diabetes that summer,[120] and that it can affect his vision if his blood sugar level is too high.