The series, which ran for four seasons from 2004 to 2008, revolves around the scientists of NorBAC (North American Biotechnology Advisory Commission), a fictional organization with a lab based in the city of Toronto.

The organization investigates problems of a scientific nature, such as bioterrorism, mysterious diseases, or radical changes in the environment throughout North America.

Through this character, the show often addresses topical social, political, and ethical issues related to the science at hand.

Aled Edwards, the scientific consultant for the series, is a noted Canadian molecular biologist, and the director of the Structural Genomics Consortium.

ReGenesis Extended Reality harnesses the power of enthusiastic fans that seed the site with discussion content and collaborative investigations.

Special features include a making of, photo gallery, and "The Facts Behind the Fiction" (the white papers published by the Ontario Genomics Institute).

The second season was later released to European countries by Buena Vista Home Entertainment, though it was presented in a pan and scan format.