In 2010 they won their last four games of the season to finish runners–up to Barnet and secure promotion to the FA Women's Premier League National Division.

[4] On 3 April 2011 Reading successfully defended the Berks and Bucks County Cup trophy, cruising past Milton Keynes Dons 3–0 in the final.

In 2012–13 Reading FC Women won the FA Premier League Southern Division by eight points and a goal difference of 41,[8] while both the first and reserve team retained the County Cup.

[9] Reading's top scorer in 2012–13, Fran Kirby, was rewarded for her campaign by being named as Player of the Season – as well as receiving a call up to play for Great Britain in the World University Games in Kazan, Russia.

[17] In June 2024, before the start of the following season and after a failed takeover bid for the club, Reading asked to withdraw from the Women’s Championship due to continuing financial difficulties.

Sell Before We Dai, a fan group calling for an owner change at Reading, described the withdrawal from the Women’s Championship as "an absolute disgrace".

[18] In August 2024, following their demotion to the Southern Region Women's Football League, Reading announced that they would move their home games to Slough Town's Arbour Park.

[23] Before then, they played at Rushmoor Community Stadium in Farnborough, Hampshire before moving to Adams Park in High Wycombe, Buckinghamshire.