"Ready to Take a Chance Again" is a 1978 international hit single performed by Barry Manilow.

It is the theme song of the movie, Foul Play, starring Goldie Hawn and Chevy Chase.

The song recounts the experience of a despairing man who has been hurt by love and therefore has retreated into the safety of an emotional shell.

The only source for this song in true stereo is the original Foul Play soundtrack, which is missing some elements of the single (a harp at 0:25 and orchestration beginning at 0:45, and a piano glissando at 2:18 is mixed way down).

In Germany, "Ready to Take a Chance Again" was backed with the re-release of "Mandy," which had been only a minor hit on its prior release.