The Audiencia consisted of eight oidores (or jueces letrados, "learned judges"), two prelates and the chancellors of justice, who were in charge of sealing documents.
By this time, the Valladolid Chancillería had come to consist of a governor (or regent), sixteen oidores (or "civil-case judges"), three alcaldes del crimen, grouped into four civil chambers, one criminal and one for cases among hidalgos and nobles.
It was during the reign of the Catholic Monarchs, Isabella I and Ferdinand V, that its permanent seat in Valladolid was confirmed by the 1489 Ordinances of Medina del Campo.
This was originally constructed in the mid-fifteenth century as a fortified palace for Alonso Pérez de Vivero, Contador mayor ("chief treasurer") of John II.
When the Vivero family lost possession of the palace, the Crown adapted it for the Chancellería and carried out other renovations including the central cloister.