Production on the album was handled by DJ Khaled, The Neptunes, Trackmasters, J. R. Rotem, Just Blaze, Reefa, and Scott Storch, among others.

Guest vocalists on Real Talk include Lil' Mo, Pharrell Williams, Mike Shorey, Charlie Murphy, Jasmin Lopez, Sean Paul, Thara, Nate Dogg and Young Jeezy.

It debuted at number six on the US Billboard 200, selling 179,000 copies in its first week and has been certified gold by the Recording Industry Association of America (RIAA).

Tindal of HipHopDX praised Fabolous for remaining consistent in delivering club bangers ("Tit 4 Tat"), romantic slow jams ("Baby") and street cuts ("Don't Stop Won't Stop"), saying "There are always the pure exotic street flow wit hard punch lines to the gut that Fab delivers as well as the smoothly shaped ballads that he always dishes out the chicks.

"[5] Steve Jones of USA Today praised Fabolous' lyricism having more direct sharpness and maturity to elevate the record's "brash confidence" alongside the usual hip-hop tropes, concluding that, "In the past, his hits have tended to lean toward female fans.