It depicts the travails of the titular characters as they take a shipment of advanced drugs from Colombia to San Francisco in what writer David Quantick has described as a "post-Burgess, post-trance-house future".

[4] In Teknograd, an enclave of young Russian scientists located in the Colombian jungle, Really and Truly are employed by Dmitri to run a consignment of bullets - a narcotic that can be inserted into the ear, producing "head shooms that last for days".

On a comfort break Truly is nearly attacked by mutants but saved by the awful verse of beat poet Scuba Trooper, who promptly joins them to get a lift to Mexico, where they are ambushed by the gigantic House of Fun, Nice's huge mobile base.

They escape but end up in Anyville, a fifties Americana theme park filled with robots and a lone human, Native American Kicking Bird.

Richard Bruton of Comicon.com disliked the story, considering it derivative of the material often seen in Deadline, "packed with drugs and forced wackiness", but was thankful for the "brilliance" of Hughes' art.