Unlike previous compilation albums, Reba #1's is the first to include material from both her MCA catalog along with her early time at Mercury Records.

As of April 2017, the compilation has sold 1,195,800 copies in the United States, having gone on to be certified 2× Platinum by the RIAA due to it being a double-disc project.

The Tim Menzies and Tony Haselden-penned track, "Love Needs a Holiday", peaked at number 60, becoming McEntire's worst performing single since the 1970s.

Of the 33 singles included, 22 of those singles ("Can't Even Get the Blues", "You're the First Time I've Thought About Leaving", "How Blue", "Somebody Should Leave", "Whoever's in New England", "Little Rock", "What Am I Gonna Do About You", "One Promise Too Late", "The Last One to Know", "Love Will Find Its Way to You", "I Know How He Feels", "New Fool at an Old Game", "Cathy's Clown", "You Lie", "For My Broken Heart", "Is There Life Out There", "The Heart Won't Lie", "Does He Love You", "The Heart Is a Lonely Hunter", "How Was I to Know", "If You See Him/If You See Her", and "Somebody") topped the US Billboard Hot Country Songs chart; the remaining 11 topped either the country charts of Radio & Records or the Gavin Report.

[5] Reba #1's debuted at number three on the US Top Country Albums chart behind Kenny Chesney's The Road and the Radio (2005) and Carrie Underwood's Some Hearts (2005), selling 117,000 copies in its first week.

[7] It is her highest charting project since her previous compilation album Greatest Hits Volume III: I'm a Survivor (2001) debuted at number one.