De Mornay is also known for her roles in The Slugger's Wife (1985), Runaway Train (1985), The Trip to Bountiful (1985), Backdraft (1991), and The Hand That Rocks the Cradle (1992).

Her other film credits include The Three Musketeers (1993), Never Talk to Strangers (1995), Identity (2003), Lords of Dogtown, Wedding Crashers (both 2005), and Mother's Day (2010).

In 1985, she played the title role in The Slugger's Wife opposite Michael O'Keefe, and co-starred in The Trip to Bountiful and Runaway Train, both of which were nominated for several Academy Awards.

She also appeared in Roger Vadim's provocative 1988 remake of And God Created Woman, and as the wife of Kurt Russell's character in Ron Howard's Backdraft (1991).

In 2004, she guest-starred as attorney Hannah Rose for the last few episodes of The Practice and the following year, had a brief role alongside Owen Wilson and Vince Vaughn in Wedding Crashers.

[4] In June 2007, she appeared in the HBO series John from Cincinnati with a starring role as matriarch of a troubled Imperial Beach, California, surfing family and the grandmother/guardian of a teen surfer on the brink of greatness.

In 2012, De Mornay played the role of Finch's mom in the movie American Reunion where she portrayed an attractive older woman and a love interest of Stifler.

They met in 1981 on the set of One from the Heart[21] and dated until De Mornay and Tom Cruise began an affair while filming Risky Business in 1982.