She was the first teacher to graduate from the Jewish Theological Seminary, New York City and took special courses at Columbia and Yale Universities and Hartford College of Law, etc.

[2] She began her career in social work in New York City as an investigator for the United Hebrew Charities, later serving as Assistant Superintendent at Beth Israel Hospital, Y.W.H.A.

During World War I, Affachiner was Assistant Regional Director of the American Embarkation Center in Le Mans, leaving for France with the first women's unit of the Jewish Welfare Board.

[3] In 1926, she made a tour of Palestine, Egypt, Italy, and the Near East; upon her return to America she was appointed the first National Field Secretary of Hadassah, of which she was a charter member.

She used what was at hand, cutting up a simple bed sheet, sewing it into a flag with the six-pointed star and stripes, and coloring it with a blue crayon[4][5] She died in Jerusalem in 1966 and was buried there in the Sanhedria Cemetery.