She played college basketball at the University of Connecticut, where she was a member of the team that won the 1995 national championship, going 35–0 on the season in the process.

In April 2017, she was one of the members of the 2017 class of the Naismith Memorial Basketball Hall of Fame, alongside Tracy McGrady and Muffet McGraw.

[8] She was a member of the inaugural class of inductees to the University of Connecticut women's basketball "Huskies of Honor" recognition program.

In 1997, the WNBA was formed and enjoyed its inaugural season, and Lobo was assigned to the New York Liberty during the league's first player allocations on January 22, 1997.

Her debut game was played on June 21, 1997, in a 67 - 57 victory over the Los Angeles Sparks where she recorded 16 points, 6 rebounds and 3 assists.

[citation needed] Lobo suffered a setback in 1999, tearing her left anterior cruciate ligament and her meniscus in the first game of the season.

[35] Today, Lobo is a reporter and color analyst for ESPN with a focus on women's college basketball and WNBA games.

[40] Lobo was the 1996 spokesperson for the Lee National Denim Day fundraiser which raises millions of dollars for breast cancer research and education.

Starting in 2000, Lobo served as national spokesperson and backer for Body1.com, a consumer-targeted network of sites providing interactive content-rich information on medical technologies that treat ailments and diseases specific to body parts.

Due to her recurring problems with a torn anterior cruciate ligament (ACL), she campaigned to raise awareness of knee injury risks in women.

[41] On April 12, 2003, Lobo changed her last name to Lobo-Rushin after marrying Sports Illustrated writer Steve Rushin at the Basketball Hall of Fame in Springfield, Massachusetts.

[43] Lobo and Rushin host the weekly Ball & Chain Podcast, where they discuss current events, sports and family life.