[2][3] As a result of Brexit, the election of Donald Trump and the Fridays for Future protests, Müller decided she needed to become politically active herself and joined Volt in 2019.

[5][6] In 2020, Müller ran in the local elections in Cologne as a direct candidate for the Ehrenfeld 5 constituency and was number 5 on the party's list.

[8] She has since been a member of the expert citizens' committee for real estate for the Volt parliamentary group on Cologne city council.

[9] In 2021, Müller was Volt's federal lead candidate in the Bundestag election alongside Bamberg city councillor Hans-Günter Brünker.

[10][11][12] Müller was federal chair of Volt Germany in 2022 together with Connor Geiger, and after his resignation in December 2022 from January to June 2023 together with Tim Marton.

[17][3] Müller sees digitalisation and artificial intelligence as a central building block for progress in climate protection and economic development.