In 1845 the Lyceum received the first instruments from future physics professor and rector of the Lycée Vuk Marinković.

The Lycée was intended to provide the kind of pragmatic education needed for civil servants in the growing administration: in 1815 there were just 24 government officials, but this number grew to 672 by 1839.

[4] The first student organization in Serbia, Association of Serbian Youth, was established in this lyceum in 1847, but it was soon banned because of their criticism of the Defenders of the Constitution.

[3] The first six professors of the Lyceum were Jovan Sterija Popović, Đura Daničić, Josif Pančić, Matija Ban, Dimitrije Nešić and Konstantin Branković.

Shortly later, came Marko Marinković, Sergije Nikolić, Isidor Stojanović, Janko Šafarić, Miloš Popović, etc.