Wade Hampton "Red" Killefer (April 13, 1885 – September 4, 1958) was an American outfielder and second baseman in Major League Baseball who played seven seasons with the Detroit Tigers (1907–1909), Washington Senators (1909–1910), Cincinnati Reds (1914–1916), and New York Giants (1916).

On August 13, 1909, the Tigers traded Killefer and Germany Schaefer to the Washington Senators for Jim Delahanty.

On July 20, 1916, Killefer was traded by the Reds with Buck Herzog to the New York Giants for three future Hall of Famers: Christy Mathewson, Edd Roush, and Bill McKechnie.

After his playing career ended, Killefer was a minor league manager for 25 years, (1917–1941).

His managerial career included stints with the following teams: He was inducted in the Pacific Coast League Hall of Fame.