In March 2007, the closure of the Palm Garden Bridge for refurbishment suspended the Red Line for five months; it resumed service in September.

The line then arrives at Potomac, where it begins travelling through street trackage about a quarter mile down the tracks, crossing into the neighborhood of Beechview in the city of Pittsburgh near the former Neeld Avenue stop.

The Red Line runs through the Mount Washington Transit Tunnel, stopping at Station Square before crossing the Monongahela River on the Panhandle Bridge.

Reaching downtown at First Avenue, the Red Line proceeds underground to Steel Plaza, Wood Street and Gateway Center.

Pittsburgh Regional Transit closed seven stations along the Red Line on June 25, 2012: Santa Barbara, Martin Villa, Kelton, Neeld, Boustead, Coast and Traymore.