[4][5] According to the U.S. Census Bureau, the county has a total area of 818 square miles (2,120 km2), of which 48 sq mi (120 km2) (5.8%) are covered by water.

[17] Other notable oil and gas fields in Refugio county, at least partially, include Anaqua, Bonnie View, Fagan, Huff, La Rosa, Mary Ellen O'Connor, and McFaddin oil and gas fields.

[17] The field is a structural trap formed by an anticline on the downthrown side of the Vicksburg Fault Zone.

[21] Gas with some oil is found above these sandstones in the Oligocene Anahuac Formation, deposited in a Marine transgression, notably the "4400-foot Greta sand".

Refugio County Medical Center opened in 1940 due to a surge in the population, and underwent expansions in 1962 and 2009.

[24][25] Nicholas Fagan - early Refugio county pioneer and active participant in the Texas revolution James Power - impresario and early settler of Refugio county Thomas O'Connor - active participant in the Texas revolution and later largest land and cattle owner in the state of Texas Voting results, shown in table, show that Refugio county has become a Republican party stronghold in the 21st century.

Prior to the 21st century, Refugio county was primarily a Democratic party stronghold with some exceptions.

School districts include:[27] The portions of the county not in Woodsboro ISD are in the service area of Victoria College.

As of 2024[update] the Texas Education Code does not specify a community college service area for the Woodsboro ISD portion.