The supporting cast includes Annette Bening, Mikki Allen, Bill Nunn, Rebecca Miller, Bruce Altman and Elizabeth Wilson.

The film received mixed reviews with praise for the cast and Ford's performance but criticism for its perceived sentimentality.

He has just won a malpractice suit, defending a hospital against a plaintiff who claims, but is unable to prove, that he warned doctors about a pre-existing condition.

Running out to a convenience store to buy cigarettes one night, Henry is shot when he interrupts a robbery.

While in a nursing facility, he slowly regains movement and speech with the help of a physical therapist named Bradley.

He confronts Sarah, and she admits to the brief affair, but reminds Henry that they’d been unhappy in their marriage for a long time.

Vincent Canby of The New York Times described the film as "a sentimental urban fairy tale" that "succeeds neither as an all-out inspirational drama nor as a send-up of American manners.

This is a film of obvious and shallow contrivance, which aims without apology for easy emotional payoffs, and tries to manipulate the audience with plot twists that belong in a sitcom."

[4] Rita Kempley of The Washington Post called the film "a tidy parable of '90s sanctimony"[5] while Peter Travers of Rolling Stone described it as a "slick tearjerker" that "has a knack for trivializing the big issues it strenuously raises."

[6] Variety, however, called the film "a subtle emotional journey impeccably orchestrated by director Mike Nichols and acutely well acted.

The site's critics consensus reads, "Although Harrison Ford makes the most of an opportunity to dig into a serious role, Regarding Henry is undermined by cheap sentiment and clichés.