Where it was positioned was some distance away from the Porta Praetoria which was a northern gate of Regensburg's old legionary fortress called Castra Regina.

Niedermünster burned down in 1273, and because of the good economic status of Regensburg at the time a new cathedral was able to be constructed.

[2] The architect that took over supervision over the new cathedral in 1280 was trained in France, and because of this there was an incorporation of French Gothic architectural themes.

One of the cathedral's builders, Mathes Roriczer, documented a way to determine architectural proportions from a ground plan.

This technique, called ad quadratum or "of quadrature," depicts elevation on a ground plan using a series of polygons.

[3] In the 17th century, the cupola located at the transept’s crossing, along with other sectors of the cathedral, were renovated in a Baroque style.

Another project the organization was involved in occurred in the 1980s, where the construction of the crypt mausoleum and archaeological exploration of the center nave were carried out.

In testimony of that Romanesque precursor, the Eselsturm ("donkey tower") still stands on the north side of the cathedral; it was used in the past and is still used to transport construction materials to the upper levels.

The Virgin and the Angel Annunciate are two notable, monumental sandstone statues located on two pillars of the west crossing piers.

In the western part of the central nave stands a bronze memorial for the Prince-Bishop Cardinal Philipp Wilhelm (d. 1598), the brother of Duke Maximilian I of Bavaria.