In his four seasons at Georgetown, he was amongst career leaders in scoring, rebounding, assists and steals in school history, finishing no lower than seventh in any category.

As a freshman, he scored 19 points and grabbed seven rebounds against the University of Houston in the 1984 national championship game which the Hoyas won 84–75.

Because of Williams's play, it led Georgetown coach Thompson to dub the team "Reggie and the Miracles".

[6] In the 1994 NBA playoffs, Williams played a key role in Denver's unprecedented upset of the SuperSonics in the first round.

In July 2021, sportswriter Bill Simmons said “I still feel like if Reggie Williams goes to a different team, his entire career is different.