She became popular for her role as Bibi P. Luche, the "weird" girl in the television series La familia P. Luche, working alongside comedians Eugenio Derbez and Consuelo Duval.

In 2003, she debuted on film in El misterio de la Trinidad earned her the Ariel for Best Supporting Actress.

In 2013, Blandón starred as Maria, Patricia and Ana in Nacho Cano's musical Hoy No Me Puedo Levantar.

In the same year, she debuted in the Canal 5 program Me caigo de risa.

In 2016, Blandón was in El hotel de los secretos as Matilde, the best friend of Irene Azuela's character, sharing credits with Erick Elías.