She was most known as a popular and influential composer of Lutheran choir anthems, hymns and liturgical pieces.
She obtained two degrees simultaneously in 1922 at Augustana College, in Rock Island, Illinois, in music and English, and studied at Juilliard graduating in 1927 with a diploma in organ.
[4] She was responsible for the Setting Two of the Service Book and Hymnal of the Evangelical Lutheran Church in America, on which she worked between 1948 and 1958.
It was called the "Continental Setting" because it reflected the Lutheran liturgy from Northern Europe, including Sweden.
It has been noted by many musicians that this loss reflected in Regina Fryxell's music which expressed joy, and a voice of the human need.