One elder brother, Cornelius Vanderbilt III (1873–1942),[7] married Grace Wilson against his parents' wishes and was disinherited.

[11] Before their divorce in 1920,[12] the couple had one daughter:[6] Cathleen Vanderbilt (1904–1944),[13] who married Henry Cooke Cushing III (1895–1960) in 1923.

Reginald Claypoole Vanderbilt died from cirrhosis due to alcoholism on September 4, 1925, at his country home, Sandy Point Farm, in Portsmouth, Rhode Island.

[6][18] In his will, he left the vast majority of his estate to his daughters with a residue to his widow, which was not to exceed $1,125,000 and his New York townhouse, located at 12 East 77th Street, and Sandy Point Farm.

[citation needed] Through his eldest daughter, Vanderbilt was the grandfather of Henry Cooke Cushing IV (1924–2000),[20] who was married to Georgia Walters "Georgette Windsor" (b.