According to the statements of a later era, Regino was the son of noble parents and was born at the stronghold of Altrip on the Rhine near Speyer at an unknown date.
Regino's earliest work was Epistola de harmonica institutione, a treatise on music which he wrote in the form of a letter to Archbishop Radbod.
[citation needed] The first book contains broad narratives on the fortunes of various rulers and church men, which are organised against the regnal spans of Roman and Byzantine emperors, and ends in the year 741 with the death of Charles Martel.
It consists of extracts taken from Bede, Paulus Diaconus, the Deeds of Dagobert, the Annals of Saint-Amand and the chronicle Liber Historiae Francorum.
[6] Regino's chronicle is an important source on Bulgarian medieval history in that it is the only contemporary text hinting at the organisation of the Council of Preslav ("… [Boris I] gathered his entire empire and placed his younger son [Simeon I] as prince…").
The title of the work in Migne's edition is Libellus DE ECCLESIASTICIS DISCIPLINIS ET RELIGIONE CHRISTIANA, COLLECTUS Ex jussu domini metropolitani Rathbodi Trevericae urbis episcopi, a Reginone quondam abbate Prumiensis monasterii, ex diversis sanctorum Patrum conciliis et decretis Romanorum pontificum.
Around 900, Regino lists four distinctive features of ethnicity: genus (origin, race), mores (customs, behavior), lingua (language), and leges (law).