The Football Federation of the Region of Murcia (Spanish: Federación de Fútbol de la Región de Murcia; FFRM) is a regional association under the control of the Royal Spanish Football Federation (RFEF), which organises official competitions within the Murcia region of Spain, including football, futsal and beach soccer.

On 27 July 1924, two clubs, Murcia and Albacete, seceded from the Levantina Federation on September 7, 1924,[1] creating the Murcia Regional Federation Club-Foot ball, which changed its name to the term "Foot-ball" in 1941, and remained under that name until 1990 when it adopted the current name.

[1] In 1928 the territorial scope of the new federation was extended to cover most of the clubs in the province of Alicante.

It further expanded in 1932 to cover the province of Almeria, and in 1933 those in the regions of Baza Granada and La Sagra.

The Albacete clubs left to join the newly created Football Federation of Castilla La Mancha in 1986.