In 1964, the garden was moved to a three-quarter-acre site on the northeast corner of Iowa State University's campus, north of the power plant.

[7][8] Until 1975 the current Reiman Gardens site was used as a grain storage facility with pens for swine, cattle, and sheep.

The new building made the Gardens a year-round facility with an indoor plant conservatory, a butterfly glasshouse "wing", an auditorium for classes and events, a gift shop, a cafe, an events hallway, greenhouses, a head house, staff offices, and two large areas housing all the heating and cooling and greenhouse systems equipment.

The Maintenance Building was constructed just north of the Conservatory Complex, in between Jack Trice Stadium and the Gardens.

[21][22] Architects Smith Metzger designed the Christina Reiman Butterfly Wing, the Mahlstede Learning Center, Conservatory Complex and Marge Hunziker House.

[26] In 2018, the Hillside Water-Wise Garden opened, the first project completed of the 20-year Master Plan that was released to the public in January 2016.

[9] In 2020, the front entrance to Reiman Gardens had its walkway repaved and the wooden trellis structure was replaced.

Elwood the World's Largest Concrete Gnome had new stairs with a railing installed thanks to a donation from John and Linda Schuh.

A pergola was installed at the top of the Hillside Water-Wise Garden thanks to a donation from Joyce and Bud Nichol.