Relamorelin

Relamorelin (INN, USAN) (developmental code names RM-131, BIM-28131, BIM-28163) is a synthetic peptide, centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) which is under development by Allergan pharmaceuticals for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa.

[1][2][3] It is a pentapeptide and an analogue of ghrelin with improved potency and pharmacokinetics.

[3] As of June 2015, relamorelin is in phase II clinical trials for diabetic gastroparesis and constipation.

[5] The United States Food and Drug Administration (FDA) has granted Fast Track designation to relamorelin for diabetic gastroparesis.

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