Opriș was born in Ploiești, graduating from the Ion Luca Caragiale High School in 1977, and from the Bucharest Carol Davila General Medicine and Pharmacy Faculty in 1983.
[1] Joining the PNȚ-CD after the 1989 Revolution, Opriș became leader of its youth organization on 1991 (serving until 1993), a junior member of its Leadership Bureau (1991–1995, during the time when the party was headed by Corneliu Coposu) and its Vice President in 1996.
[1] In December 1996, after the election victory, Opriş was appointed to ministerial office, as Minister-Delegate for Coordinating the General Secretariat of the Government and of the Department for Local Public Administration.
[1] During the new Radu Vasile government, Remus Opriș was also noted for his criticism of Democratic Party (PD), the CDR's coalition partner, and condemned the decision taken by Radu Berceanu, the PD's Minister of Industry and Commerce, to replace PNȚ-CD-appointed members of the administrative boards for state-owned enterprises such as RENEL and ROMGAZ.
[5] In March 2006, he rejected the offer of fusion proposed by the PD, aimed at creating a "center-right pole" in Romanian politics, and indicated that the National Peasants' Party would carry on as an independent force.