He studied at the École nationale supérieure des beaux-arts of Paris and later with Fernand Léger friend of Maurice Utrillo and Bernard Buffet.
His paintings can be found in many prominent private collections throughout the United States and Europe, including that of the Swiss Consulate in Paris.
Between 1989 and 1993 he created many stained glasses windows in France for Church of St. Martin in Valaurie, Basilica of Saint Martin, Tours, and Basilica of St. Pius X in Lourdes where 20 gemmails ("the way of light") will be made, on the appearances of Bernadette SoubirousAlthough Margotton used watercolors early on in his career, he later experimented with oils and continued to work almost exclusively in that medium.
A mediaeval fort with embellishments dating from the 15th and 17th century, the entire construction a classified historical monument, the Bishops' Palace of Bourg-Saint-Andéol is one of the largest and most complex in the Vivarais region.
Inside the museum René Margotton, the "Painter of Light"'s sacred works, displayed in a 19th-century neo-gothic chapel, and also in the "mystery" room.