When Francis acceded to the French throne as Francis I, René was made governor of Provence and grand sénéchal of Provence in 1515,[3] then Grand Master of France (surintendant of the Maison du Roi) by letters patent of 31 October 1519, posts he held until his death.
This ship left Marseille on 24 August 1520 to protect the Knights Hospitaller against an attack by the Turks, returning there on 6 January 1521.
In May 1522, the ship took part in the expedition to aid Genoa, commanded by René as admiral and by Pedro of Navarre as lieutenant general.
[4] After René's death, Louise of Savoy put a value-estimate on the ship and it was bought by Francis I from the countess of Villars and Tende between July and August 1526.
On 28 January 1501, he married Anne Lascaris, countess of Tende (1487–1554), daughter and heiress of Jean-Antoine Lascaris, Count of Tende and Ventimiglia, dame of Chateau Montfort in La Colle sur Loup, and of Isabelle d'Anglure, widow of Louis de Clermont-Lodève, with whom he had the following children:[4]