[3] In 1977, Missel partnered with Howard Rosenman to co-produce the Warner Brothers hit romantic comedy The Main Event (1979), starring Barbra Streisand and Ryan O'Neal.

Bomb, an anti-nuclear film parodying government nuclear preparation information, which was withdrawn from exhibition after one showing by Laemmle Theatres.

[9] After leaving ABC, she co-wrote My Man Adam (1986) with her then-husband Roger L. Simon;[10] she also produced the film, which starred Veronica Cartwright and Raphael Sbarge.

She left DDL in 1988 and joined Taylor Hackford's New Visions Pictures to produce the film noir-thriller Defenseless (1991), starring Barbara Hershey and Sam Shepard.

Within a few years, she left The Samuel Goldwyn Company to develop the script for Nell (1994), the motion picture adaptation of Idioglossia.

[21] During her tenure, honorees included Jodie Foster, Sir Anthony Hopkins, Sean Penn, Anjelika Houston, Ben Kingsley, Whoopi Goldberg, Diane Keaton, Rob Reiner, Julie Christie, John Schesinger, Richard Pryor, and Robert Towne among others.