After a short stay in Stuttgart, the family moved to Berlin in 1905, where her father had received a job at the higher court.

Sintenis took drawing lessons while she was still at school, which was followed by studies in decorative sculpture at the teaching institution of the Museum of Applied Arts in Berlin, with Wilhelm Haverkamp and Leo von König in 1907.

She finally evaded the unwanted activity by breaking with her family, which caused her severe problems, including depression, for a long time.

[1] In 1917 she married the type artist, book designer, painter and illustrator Emil Rudolf Weiß, whom she had met years earlier as her teacher[2] and fatherly friend.

Their collaboration was limited to a few joint projects, of which the edition of the 22 Songs of the poems by Sappho, for which she created the etchings and Weiß made the font designs, achieved particular fame.

In addition, due to her height, slim figure, charisma, her self-confident, fashionable demeanor and androgynous beauty, she was often portrayed by artists like her husband, Emil Rudolf Weiß and Georg Kolbe, and by photographers, like Hugo Erfurth, Fritz Eschen and Frieda Riess.

Her small-sized depictions of athletes (boxers, footballers, runners) and portrait busts of their circle of friends were found in public and private collections around the world.

In 1928 Sintenis won the bronze medal in the sculpture section of the art competition for the Summer Olympics in Amsterdam, for her "Footballeur".

[4][5] Renée Sintenis took part in the 1929 exhibition of the German Association of Artists in the Cologne State House, with five small-format animal sculptures.

[1] Emil Rudolf Weiß was dismissed from his university post on 1 April 1933, because of an angry statement against the Nazi regime and the law to reintroduce the civil service.

After the war, Sintenis and her partner Magdalena Goldmann moved into an apartment on Innsbrucker Strasse in 1945, where they both lived until their deaths.

[1] In 1957, Sintenis' statue of the Berlin Bear was erected as a life-size bronze sculpture on the median of what is now the Bundesautobahn 115 between Dreilinden and the Zehlendorf motorway junction.

On 6 June 1962, a bronze monument of the Berlin bear was erected in the median of the Bundesautobahn 9 at the level of today's junction Munich-Fröttmaning-Süd.

In 2018, her work was included in the exhibition Lesbian Visions, curated by Birgit Bosold and Carina Klugbauer, at the Schwules Museum in Berlin.

[7] A bear created by Noack in 1976 stands in Griffith Park, Los Angeles, with a plaque reading "To the people of the United States of America in gratitude for their aid, friendship and protection.