During the season, the car turned out to be slower than the McLaren MP4-20 at numerous points, with the win tally being 8–10.

The R25 was the first Constructors' Championship winning car since 1991 not to have been designed by either Adrian Newey or Rory Byrne.

Over 19 races, it scored 191 points, 8 wins, 15 podiums and was fully out of the points just twice in 18 starts (not counting the United States Grand Prix where both Renault drivers, in common with all their fellow Michelin tyre runners, withdrew prior to starting).

In Episode 8 of Series 10 of the BBC show Top Gear, in 2007, presenter Richard Hammond drove the R25 around the Stowe Circuit at Silverstone, completing two laps.

[5] On 11 December 2020 Alonso drove the car for the first time in 15 years, hours before the start of the first practice session shown on Sky Sports,[6] and after the qualifying session for the 2020 Abu Dhabi Grand Prix.