It is represented by John Yakabuski of the Progressive Conservative Party.

Renfrew—Nipissing—Pembroke includes all of Renfrew County and a small section of Nipissing District around Algonquin Provincial Park.

The largest community in the riding is the city of Pembroke; other communities include Arnprior, Barry's Bay, Chalk River, Cobden, Deep River, Eganville, Killaloe, Petawawa and Renfrew.

Until recently, the riding was a Liberal stronghold both federally and provincially; however, a growing agricultural and religious base has turned this into one of the most conservative areas in Ontario.

It was the only riding the Liberals had and lost in the 2003 provincial election.