They made a number of structural changes to the company, including the closure of the main offices at Felcourt, near East Grinstead, relocating them to Belgrave House, Victoria, Central London and City Place, Gatwick.

They also presided over a succession of profit warnings, mainly as a result of the problematic integration of the 2006 acquisition of Target Express into the existing City Link business.

[12] In the following year Rentokil sold the Initial Fire, Electronic Security and staffed guarding businesses, previously known as Shorrock, to United Technologies Corporation.

[7] In February 2011, the company acquired the Fumigation & Pest Control, Water Treatment & Hygiene and Fire Safety & Prevention businesses of Santia, formerly Connaught plc, for £5.6m.

[16] The City Link division had continued to make losses, and although these had reduced following major management/structural changes, the company was disposed of in April 2013 to Better Capital plc for £1.

[17] On 1 August 2013, the company announced that CEO Alan Brown would be stepping down and would be replaced by Andy Ransom on 1 October.

[24] In 2018, Rentokil Initial plc announced a new partnership with Cool Earth to support its work in Papua New Guinea, protecting around 1,000 acres of rainforest and so preventing the release of at least 228,000 tonnes of CO2 emissions, equivalent to the company's entire carbon footprint.

In the same year, it was awarded Britain's Most Admired Company for Diversity & Inclusion and topped the league table of the UK's Best Workplaces in the private sector, according to data released by the world's biggest job site, Indeed.

[29] In April 2022, Rentokil North America acquired JP Pest Services which operates throughout New England.

[31] In April 2024, it was announced Rentokil Initial had acquired the Indian pest control company, Hicare, for an undisclosed amount.

[33] Additionally, the company continues to operate local brands under the names of acquired businesses which have a familiar brandname in their respective markets, such as JC Ehrlich, Western Exterminator,[16] and Terminix.