In 1975 The Imaginary Theater Company begins bringing The Rep's work to schools and younger audiences.

[4] The Rep was Founded in 1966 and made its home at Webster University's Loretto-Hilton Center for the Performing Arts.

The first production at The Rep was two Peter Shaffer plays "The Private Ear" and "The Public Eye" presented together.

[8][9] In 2021 Mark Bernstein retired as Managing Director and was replaced by Danny Williams[10][11][12] The Rep's home at Loretto-Hilton Center is shared with the Opera Theatre of Saint Louis, as well as The Conservatory of Theatre Arts at Webster University and Webster University's dance department.

[13] Notable Highlights from past seasons include: The 50th anniversary season of shows in 2016-2017 which included: Follies, The World Premiere of Dael Orlandersmith's Until the Flood, A Christmas Carol, All My Sons, To Kill a Mockingbird and Million Dollar Quartet[14]