Reports from the Holocaust contains a diverse selection of Kramer's nonfiction writings focused on AIDS activism and LGBT civil rights, including letters to the editor and speeches, which document his time spent at Gay Men's Health Crisis, ACT UP, and beyond.

The central message of the book is that gay men must accept responsibility for their lives, and that those who are still living must give back to their community by fighting for People With AIDS (PWA's) and LGBT rights, for, as Kramer states, "I must put back something into this world for my own life, which is worth a tremendous amount.

Kramer raises the question of whether modern LGBT organizations are complicit in the oppression of their own members and the Holocaust that is AIDS, by cooperating with heterosexual society and passively collaborating in the genocide against gay men that Kramer recognizes AIDS to be, making them into gay "Uncle Toms" that value their own personal finances and prestige at the expense of the LGBT individuals and PWA's they claim to represent.

[2] Toward the goal of preventing this occurrence, the collection contains information for individuals that are committed to social justice but currently corralled in nonprofit LGBT organizations that refuse to adopt a political stance.

Kramer contends that, from a practical perspective, if the Catholic Church, the Salvation Army, the American Cancer Society, and Sloan-Kettering can pursue political activism while preserving their nonprofit status, so too can organizations who fight for LGBT rights and People With AIDS.

In some sections of the book, Kramer focuses on the concept of individual empowerment, and how those who feel powerless may gain influence by taking responsibility, even for what would appear to be insignificant, mundane tasks.

Through speeches, editorials, and personal, sometimes publicized, letters to figures such as politician Gary Bauer, former New York Mayor Ed Koch, several New York Times reporters, and head of the National Institute of Allergy and Infectious Diseases, Anthony Fauci, Kramer personally advocates for a more significant response to AIDS.

Kramer also describes his frustration with many members of the gay community that do not actively advocate for PWAs and AIDS research, stating that they are complicit in their own deaths.

For example, he informs the reader that during one speech, "I delivered this list while staring Cardinal O'Connor right in the eye,"[8] and reveals at another point that, "the audience for this symposium appeared to be composed mostly of elderly men and women, with nothing else to do, who filled their days attending activities like this one, costing nothing.